Ingrid's Lab finds out research on memory recovery and publishes international journal

Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice

2022年8月1日

There are more than 290,000 people with dementia in Taiwan, among which Alzheimer's disease has the highest proportion. The molecular neurology experimental team of Tzu Chi University recently proposed a mechanism that can help Alzheimer's mice recover working memory, which was published in an international journal , providing new opportunities for research.


The main symptom of Alzheimer's disease is memory deterioration, and many scientists want to find out how to activate memory in the brain.


Liu Yijun, President of Tzu Chi University: "To regulate these two functions, increase the function of autophagy, reduce the inflammatory response, and bring it to a more balanced state. We found that the working memory of the mice came back."


The Molecular Neurology Laboratory of Tzu Chi University focuses on studying the molecular mechanisms of memory formation and degradation. A few days ago, the team fed Alzheimer's mice with Chinese herbal extracts and found that it can effectively inhibit the inflammatory response and improve the working memory of the mice.

Liu Yijun, President of Tzu Chi University: "When we added an effective compound, its long-term memory improved like that of a normal mouse. This is a good cytological evidence, which promotes the conduction rate of cells, so nerve conduction becomes effective." Efficiency improves, and memory naturally improves.”


The Chinese herbal extract is in the process of patent application, and this paper has also been published in international journals. The main author is Pavi, who came from India to study at Ciudad University. In the team, she learned the spirit of perseverance as a scientist.


Pavithra Suresh, a doctoral student at Tzu Chi University of Medicine: "I think patience is the most important thing for a doctoral student. The relationship between our team is very good. When my paper was published last week, they were happier than myself. Friendship is very important to me. It is the most beautiful thing.”

The team looks forward to finding more mechanisms for reversing Alzheimer's memory deficits in the future to benefit more people.


台灣失智人口超過29萬,其中以阿茲海默症的比例最高,慈濟大學分子神經學實驗團隊,日前提出有助阿茲海默小鼠工作記憶恢復的機轉,獲得國際期刊的刊登,提供研究新契機。 阿茲海默症主要症狀在記憶退化,許多科學家都想找出活化腦部記憶的方法。 慈濟大學校長 劉怡均:「去調節這兩個作用,把自噬作用的功能拉高,把發炎反應降低,把它拉到比較平衡的狀況,我們發現說老鼠的工作記憶就回來了。」 慈濟大學分子神經學實驗室,以研究記憶形成與退化的分子機轉為主。日前團隊以中草藥萃取物餵食阿茲海默小鼠,發現能有效抑制發炎反應,提升小鼠的工作記憶。 慈濟大學校長 劉怡均:「我們加了有效的化合物的時候,牠的長期記憶像正常老鼠一樣起來了,這就是一個很好的細胞學證據,促進了細胞的傳導速率,所以神經傳導變得有效率了,記憶自然變好了。」 中草藥萃取物正申請專利中,而這篇論文也獲得國際期刊的刊登,主要作者是從印度來慈大讀書的Pavi,在團隊中,她學習到鍥而不捨的科學家精神。 慈大醫科所博士生 Pavithra Suresh:「我想對一個博士生而言,耐心是最重要的,我們團隊的關係非常好,上周當我的論文刊登,他們比我自己還高興,友誼對我而言是件最美好的事。」 團隊期待未來,能找到更多反轉阿茲海默症記憶缺損的機轉,造福更多人。 唐嬋君 鍾江波 劉泓志 花蓮報導


5 次查看
Featured Posts